Stimulation of Gastric Acid Secretion by Irrigation of the Antrum with Some Aliphatic Alcohols1
作者:
Carl‐Eric Elwin,
期刊:
Acta Physiologica Scandinavica
(WILEY Available online 1969)
卷期:
Volume 75,
issue 1‐2
页码: 1-11
ISSN:0001-6772
年代: 1969
DOI:10.1111/j.1748-1716.1969.tb04349.x
出版商: Blackwell Publishing Ltd
数据来源: WILEY
摘要:
AbstractEthyl alcohol is known to stimulate gastric acid secretion in fundic pouch dogs during irrigation of the antrum. A comparison was made with regard to such an effect of a series of aliphatic alcohols including methyl, ethyl, n‐propyl, isopropyl, n‐butyl, isobutyl, sec‐butyl and tert‐butyl alcohol. Dogs provided with a Heidenhain or a Pavlov pouch and isolated, innervated antral pouch were used. The only alcohol besides ethanol that showed a potent stimulatory effect was n‐propyl alcohol. All other alcohols tested had an effect less than half of that of ethanol. A change from one stimulatory alcohol to the corresponding isocompound caused a marked decrease of the effect. Isopropyl alcohol, one of the “non‐stimulatory” aliphatic alcohols, did neither show a synergistic nor an inhibitory action on the effect of ethyl alcohol or n‐propyl alcohol during simultaneous administration, indicating almost no interference with gastrin release mechanisms. n‐Propyl alcohol together with ethyl alcohol showed a dose‐response related action. Methyl alcohol was almost inactive. The results indicate that the stimulatory effect of alcohols could not be related to water or fat solubility but to the mo
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