Vasoactive Intestinal Polypeptide: Measurement, Distribution and Putative Neurotransmitter Function
作者:
Jan Fahrenkrug,
期刊:
Digestion
(Karger Available online 1979)
卷期:
Volume 19,
issue 3
页码: 149-169
ISSN:0012-2823
年代: 1979
DOI:10.1159/000198339
出版商: S. Karger AG
关键词: Neurotransmitter;Radioimmunoassay;Vasoactive intestinal polypeptide (VIP);VIPergic neurons
数据来源: Karger
摘要:
Vasoactive intestinal polypeptide (VIP) is a highly basic octacosapeptide isolated from porcine small intestine. VIP was originally considered to be a gut hormone, but radioimmunochemical and immunohistochemical studies have revealed that VIP has a widespread distribution localized in neurons. VIP-containing neurons are present in the central nervous system including the cerebral arteries, the digestive tract, the genitourinary tract and the adrenal glands. In the nerve terminals VIP is localized in synaptic vesicles. VIP fulfils a number of criteria to be a neurotransmitter both in central and peripheral nerves. Whilst the role of VIP in the central nervous system is unknown, it is likely that VIP is the mediator of gastrointestinal and pancreatic functions, which are controlled by non-cholinergic, non-adrenergic nerve fibres.
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