Improvement of Immune-Complex Nephritis Associated with Hepatitis B Surface Antigen Excess
作者:
Eyal Raz,
Joseph Michaeli,
Mayer Brezis,
Mordecai M. Popovtzer,
Yair Gazitt,
Daniel Shouval,
期刊:
American Journal of Nephrology
(Karger Available online 1989)
卷期:
Volume 9,
issue 2
页码: 162-166
ISSN:0250-8095
年代: 1989
DOI:10.1159/000167957
出版商: S. Karger AG
关键词: Hepatitis B surface antigen;Circulating immune complexes;Membranoproliferative glomerulonephritis
数据来源: Karger
摘要:
A case of hypocomplementemic membranoproliferative glomerulonephritis was studied during remission of nephrosis induced by high doses of corticosteroids. Hepatitis B surface antigen (HBsAg) and immune complexes were detected in serum and glomeruli. Anti-hepatitis-B surface antibody, undetectable in serum by conventional radioimmunoassays was identified in circulating immune complexes (CIC). On two occasions, improvement in renal function coincided paradoxically with an extreme increase in serum HBsAg levels as well as with marked elevation of CIC. We suggest that, as previously observed in animal models of glomerulonephritis, extreme antigen excess may inhibit glomerular deposition of immune complexes.
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