首页   按字顺浏览 期刊浏览 卷期浏览 Effects of Platinum Antitumor Agents onin vitroAssays of Human Antitumor Immunity
Effects of Platinum Antitumor Agents onin vitroAssays of Human Antitumor Immunity

 

作者: Michael B. Mally,   Craig Taylor,   Denis M. Callewaert,  

 

期刊: Chemotherapy  （Karger Available online 1980）
卷期: Volume 26, issue 1  

页码: 1-6

 

ISSN:0009-3157

 

年代: 1980

 

DOI:10.1159/000237876

 

出版商: S. Karger AG

 

关键词: Spontaneous cytotoxicity;Natural cytotoxicity;Cis-[Pt(NH3)2Cl2];Platinum antitumor complexes;Lymphoblast cell lines

 

数据来源: Karger

 

摘要:

The effects of cis-[Pt(NH3)2Cl2] on the spontaneous cell-mediated cytotoxicity of human lymphoblast cell lines mediated by normal human peripheral blood lymphocytes was investigated. Direct addition of cis-[Pt(NH3)2Cl2], but not its tumor inactive trans isomer, to the in vitro spontaneous cytotoxicity assay resulted in a small but significant enhancement of target cell lysis. Pretreatment of target cell lines with 5 μ m cis-[Pt(NH3)2Cl2] also resulted in a similar increase in target cell susceptibility to lysis

 

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