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Partial Degeneration of Autonomic Nerves of the Heart of Methotrexate-Treated Guinea Pigs

 

作者: M.A. Qayyum,   J.A. Fatani,   M.G. El-Badawi,  

 

期刊: Cells Tissues Organs  （Karger Available online 1988）
卷期: Volume 131, issue 1  

页码: 52-55

 

ISSN:1422-6405

 

年代: 1988

 

DOI:10.1159/000146485

 

出版商: S. Karger AG

 

关键词: Autonomic nerves;Adrenergic ner-ves;Cholinergic nerves;Degeneration;Methotrexate;Cardiotoxicity

 

数据来源: Karger

 

摘要:

In the present investigation partial degeneration of adrenergic and cholinergic nerves of the heart of guinea pigs following methotrexate treatment has been reported. No appreciable change was observed in the autonomic nerve fibres after 3 days of treatment. However, after prolonged treatment some nerve fibres showed signs of degeneration and a few adrenergic and cholinergic nerve fibres had disappeared.

 

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