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Metiamide Treatment in Five Patients with Zollinger-Ellison Syndrome

 

作者: S. Bonfils,   J.J. Bernier,   M. Mignon,   R. Lambert,   P. Bernades,   C. L’Hirondel,   J.-P. Accary,   G. Kloeti,  

 

期刊: Digestion  （Karger Available online 1977）
卷期: Volume 15, issue 1  

页码: 43-52

 

ISSN:0012-2823

 

年代: 1977

 

DOI:10.1159/000197982

 

出版商: S. Karger AG

 

关键词: Gastric juice;Gastrin;H2-receptor antagonists;Metiamide;Zollinger-Ellison syndrome

 

数据来源: Karger

 

摘要:

Five patients with Zollinger-Ellison syndrome received metiamide per os in doses ranging from 600 to 1,200 mg/day for a minimum period of 2 weeks. Drug produced an inhibition of basal gastric acid secretion ranging from 5 to 100 % with relief of symptoms. Survey of patients during and after metiamide course showed sometimes a prolonged antisecretory effect up to 26 days after the end of treatment or, on the contrary, a reduced drug activity in spite of increasing doses.

 

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