Carfecillin: Antibacterial Activityin vitroandin vivo
作者:
M.J. Basker,
K.R. Comber,
R. Sutherland,
G.H. Valler,
期刊:
Chemotherapy
(Karger Available online 1977)
卷期:
Volume 23,
issue 6
页码: 424-435
ISSN:0009-3157
年代: 1977
DOI:10.1159/000222012
出版商: S. Karger AG
关键词: Carfecillin;Carbenicillin;Antibacterial activity;MIC data;Mouse infections
数据来源: Karger
摘要:
Carfecillin, the α-phenyl ester of carbenicillin, hydrolyses rapidly in the presence of serum or body tissues to liberate carbenicillin but hydrolysis is less rapid in aqueous solution. The activity of carfecillin in antibacterial tests in vitro depends upon the extent of hydrolysis to carbenicillin, and in conventional serial dilution tests carfecillin shows an antibacterial spectrum generally similar to that of carbenicillin due to extensive hydrolysis. However, in tests in which the extent of hydrolysis is reduced, carfecillin displays lesser activity than carbenicillin against gram-negative bacilli and greater activity against gram-positive cocci. In the presence of serum carfecillin is hydrolysed rapidly to carbenicillin and the activity shown is solely that of carbenicillin. Unlike carbenicillin, carfecillin is well absorbed in mice after oral administration, producing significant carbenicillin blood concentrations and the compound is as effective by the oral route in the treatment of various experimental mouse infections as is parenteral carbenicillin
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