A comparison of the efficacy of two commercial Aujeszky's disease vaccines with glycoprotein-I deletion in pigs
作者:
M.J.X Motha,
G.W. Horner,
K-M. Tham,
J.C. Ralston,
期刊:
New Zealand Veterinary Journal
(Taylor Available online 1993)
卷期:
Volume 41,
issue 1
页码: 1-6
ISSN:0048-0169
年代: 1993
DOI:10.1080/00480169.1993.35727
出版商: Taylor & Francis Group
数据来源: Taylor
摘要:
Two commercial Aujeszky's disease vaccines, a modified killed vaccine and a sub-unit vaccine, both carrying a deletion of glycoprotein-I, were evaluated in pigs. Each vaccine was administered to two groups of four pigs, twice at 4-week intervals, with two pigs held as unvaccinated controls. All pigs were challenged with a New Zealand field isolate of Aujeszky's disease virus 3 weeks after the second vaccination. The results indicate that the sub-unit vaccine was able to protect pigs against clinical Aujeszky's disease much better than the pigs vaccinated with the modified killed vaccine when challenged with a virulent virus. However, the amount and the duration of virulent virus excretion following challenge was greater with the sub-unit vaccine than the modified killed vaccine. Pigs vaccinated with the sub-unit vaccine were shown to be latently infected following challenge. Latent infection was demonstrated by excretion of Aujeszky's disease virus from the nasal cavity after dexamethasone treatment and seroconversion of a sentinel in contact pigs to Aujeszky's disease virus.
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