Simplified Prothrombin Time Standardization
作者:
Ingebrigt Talstad,
Knut Korsbrekke,
期刊:
Pathophysiology of Haemostasis and Thrombosis
(Karger Available online 1994)
卷期:
Volume 24,
issue 1
页码: 4-13
ISSN:1424-8832
年代: 1994
DOI:10.1159/000217074
出版商: S. Karger AG
关键词: Prothrombin time;Warfarin;Protein-induced by vitamin K absence inhibitor
数据来源: Karger
摘要:
An analysis of prothrombin time (PT) standardization methods is presented. The present recommended ratio method demonstrated complex calibration and wide therapeutic ranges. Standardization by coagulation activities resulted in different therapeutic ranges due to the different sensitivity of assays for the protein induced by vitamin K absence (Pivka) inhibitor. A new method – the modified coagulation activity method – applied a reference assay against which any PT assay can be calibrated by clotting times, and the results were expressed in coagulation activities by the reference assay. This method was preferable due to simple calibration, narrow therapeutic ranges and identical results by any PT as
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