Low Molecular Weight Immunosuppressive Factors Found in Elevated Amounts in Cancer Ascitic Fluids of Mice 2. 1-Methyladenosine Isolated from Cancer Ascitic Fluids Enhances Listeria Infection in Mice
作者:
TakanoShoichi,
SamiShunsuke,
MajimaToshiro,
IshidaNakao,
期刊:
Immunopharmacology and Immunotoxicology
(Taylor Available online 1986)
卷期:
Volume 8,
issue 1
页码: 59-73
ISSN:0892-3973
年代: 1986
DOI:10.3109/08923978609031085
出版商: Taylor&Francis
数据来源: Taylor
摘要:
AbstractThe low molecular weight fraction (mol wt<1,000) of Ehrlich cancer ascitic fluid has been known to enhanceListeriainfection in mice. Chemical characterization of the entities in this fraction revealed four purine and pyrimidine analogues, i.e. uric acid, uracil, pseudouridine and 1-methyladenosine (m1Ado). When the effect of each of these components was studied onListeriainfection in mice, only m1Ado markedly enhanced the infection and killed the mice within a short period. The optimal enhancement was obtained when m1Ado was given intravenously to mice 3-6 days before the infection at a concentration of between 1 and 100μg/mouse. On the other hand, uric acid, uracil and pseudouridine failed to show such an enhancing effect. m1Ado inhibited macrophage accumulation in the peritoneal cavity of mice after an intraperitoneal injection of phytohemagglutinin. Although m1Ado did not show any inhibitory effect on the phagocytic and bactericidal activities of macrophagesin vitro.
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