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Effect of Verapamil on Platelet Surface Ultrastructure and Calcium Content

 

作者: M. Djaldetti,   R. Gilgal,   P. Fishman,   I. Zahavi,  

 

期刊: Acta Haematologica  （Karger Available online 1988）
卷期: Volume 79, issue 1  

页码: 41-43

 

ISSN:0001-5792

 

年代: 1988

 

DOI:10.1159/000205688

 

出版商: S. Karger AG

 

关键词: Platelet calcium content;Scanning electron microscopy;Verapamil;X-ray microanalysis

 

数据来源: Karger

 

摘要:

The effect of verapamil on the surface ultrastructure and calcium content of human platelets was studied by scanning electron microscopy and X-ray microanalysis. The results showed that the drug prevents platelet pseudopodia formation and causes a dose-dependent inhibition of platelet calcium concentration. The significance of these findings in the explanation of the inhibitory effect of verapamil on platelet aggregation is discussed.

 

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