ABSTRACTSix cases diagnosed as Gianotti‐Crosti syndrome were divided into 2 groups, a group with liver dysfunction and a group with normal liver function, and the other signs and symptoms of the 2 groups were compared with special attention to differences in the cutaneous findings. The eruption in the group with liver dysfunction corresponds to that of Gianotti disease and in the group with normal liver function to that of Gianotti syndrome, which led to the conclusion that the two should be differentiated. The important points of differentiation are summarized as follows:In Gianotti disease there is acute hepatitis and the eruption is monomorphous with multiple disseminated 3–4 mm in diameter, copper red, flat‐topped papules. Gianotti syndrome is without hepatitis, and the eruption consists of irregularly distributed 2–4 mm in diameter, faintly erythematous, hemispherical papules, but is frequently polymorphous, with intermingled vesicle‐like, hemorrhagic, and molluscum contagiosum‐li