Control of Chemotherapy-Induced Diarrhea with Octreotide
作者:
Stefano Cascinu,
Anna Fedeli,
Stefano Luzi Fedeli,
Giuseppina Catalano,
期刊:
Oncology
(Karger Available online 1994)
卷期:
Volume 51,
issue 1
页码: 70-73
ISSN:0030-2414
年代: 1994
DOI:10.1159/000227313
出版商: S. Karger AG
关键词: Cisplatin;Diarrhea;Octreotide
数据来源: Karger
摘要:
Cisplatin-related diarrhea is a relatively common complication in the clinical management of cancer patients and until now no treatment for this condition has been identified. Octreotide has been reported effective in the treatment of 5-fluorouracil-related diarrhea. To assess the safety and efficacy of octreotide in controlling diarrhea caused by cisplatin, 43 patients who had already had diarrhea during the 24-hour period following a previous cisplating administration were randomized to receive either octreotide or placebo during the next cisplatin course. The patients given octreotide experienced less diarrhea (5 vs. 75%, p = 0.01). There were no side effects. We conclude that octreotide is more effective than placebo in controlling diarrhea following cisplatin chemotherapy.
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