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Methyl-CCNU in Malignant Melanoma – A Divided Dose Schedule of Administration

 

作者: R.E. Wittes,   Ki Hong,   Linda Gatchell,   I.H. Krakoff,   R.B. Golbey,  

 

期刊: Oncology  （Karger Available online 1977）
卷期: Volume 34, issue 1  

页码: 45-46

 

ISSN:0030-2414

 

年代: 1977

 

DOI:10.1159/000225178

 

出版商: S. Karger AG

 

关键词: Methyl-CCNU;Melanoma;Myelosuppression

 

数据来源: Karger

 

摘要:

Methyl-CCNU (NSC-95441) was administered to patients with malignant melanoma in a split dose schedule. Nausea and vomiting were eliminated as clinical problems during therapy. Response rate to the drug seemed somewhat lower than the average of three previously reported disease-oriented phase II trials, though the difference was not significant statistically. The time course of myelosuppression seemed comparable to that seen with a single dose schedule of administration.

 

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