Treatment with Krestin® Combined with Mitomycin C, and Effect on Immune Response
作者:
Takayoshi Fujii,
Norifumi Sugita,
Yasuhiko Kobayashi,
Kenichi Saito,
Hiroko Iijima,
Kenichi Matsunaga,
Takao Ando,
Yoshiharu Oguchi,
Itsuko Morita,
Chikao Yoshikumi,
Kikuo Nomoto,
期刊:
Oncology
(Karger Available online 1989)
卷期:
Volume 46,
issue 1
页码: 49-53
ISSN:0030-2414
年代: 1989
DOI:10.1159/000226680
出版商: S. Karger AG
关键词: Krestin® (PSK);Immunochemotherapy;Mitomycin C;Antitumor effect;Delayed-type footpad reaction;Agglutinating antibody titer
数据来源: Karger
摘要:
The combination effects of Krestin® (PSK) and mitomycin C (MMC) were examined in experimental tumor models. PSK was administered either orally or intraperitoneally. Delayed-type footpad reaction and antibody formation against sheep erythrocytes were measured in hosts of which immune functions were depressed by tumor burden. Results of the experiment indicated that the simultaneous administration of PSK and MMC significantly increased the survival rate of tumor-bearing mice and restored more effectively their immune functions compared to those of nontreated tumor-bearing controls or tumor-bearing hosts treated with a single agent
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