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Stem Cell Factor Is a Potent Synergistic Factor in Hematopoiesis

 

作者: George Morstyn,   Sherri Brown,   Michael Gordon,   Jeffrey Crawford,   George Demetri,   William Rich,   Brian McGuire,   MaryAnn Foote,   Ian McNiece,  

 

期刊: Oncology  （Karger Available online 1994）
卷期: Volume 51, issue 2  

页码: 205-214

 

ISSN:0030-2414

 

年代: 1994

 

DOI:10.1159/000227335

 

出版商: S. Karger AG

 

关键词: Stem cell factor;r-metHuSCF;Synergistic action;Clinical studies;Preclinical studies;Peripheral blood progenitor cell mobilization;Lethal-irradiation protection

 

数据来源: Karger

 

摘要:

Stem cell factor (SCF), a ligand for c-kit, has a broad range of activities including effects on cells at or near the level of the multipotential stem cell as well as on committed cells. Preclinical studies show that SCF can protect against lethal irradiation, elicit multilineage responses in peripheral blood and bone marrow cellularity, and increase circulating peripheral blood progenitor cells (PBPC) in a dose-dependent manner. Recombinant human SCF has major clinical potential through its synergy with other factors, especially recombinant human granulocyte colony-stimulating factor, to enhance mobilization of PBPC.

 

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