Nature of Streptomycin Resistance in Enterobacteria from Faeces of Streptomycin-Treated Patients in Egypt
作者:
A.E. Elkhouly,
B. Wiedemann,
期刊:
Chemotherapy
(Karger Available online 1980)
卷期:
Volume 26,
issue 4
页码: 268-275
ISSN:0009-3157
年代: 1980
DOI:10.1159/000237916
出版商: S. Karger AG
关键词: Streptomycin resistance;Resistance plasmids;Enterobacteria;Resistance mutants;Clinical isolates
数据来源: Karger
摘要:
Streptomycin-resistant enterobacteria were isolated from the faeces of 31 out of 35 patients under streptomycin therapy, in the University Hospital of Alexandria. The isolated bacteria were 26 Escherichia coli, 3 Klebsiella pneumoniae and 2 Enterobacter cloacae. Their resistance patterns have shown that 80% had multiple antibiotic resistance. The MIC of streptomycin for all strains was higher than 312 μg/ml.Nearly 90% of these strains carried resistance plasmids. However, 3 strains possessed no plasmids and were assumed to be mutants. 60% of the plasmid-carrying strains have been able to transfer the resistance by conjugation. The rest have shown small plasmids, some of them were characterized by streptomycin and sulphonamide resistance and a molecular weight of 4.1 mega-daltons
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