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Chemotherapy in recurrent noncystic low‐grade astrocytomas of the cerebrum in children

 

作者: Timur Sumer,   Arnold I. Freeman,   Michael Cohen,   Alfonso M. Bremer,   P. R. M. Thomas,   Lucius F. Sinks,  

 

期刊: Journal of Surgical Oncology  （WILEY Available online 1978）
卷期: Volume 10, issue 1  

页码: 45-54

 

ISSN:0022-4790

 

年代: 1978

 

DOI:10.1002/jso.2930100108

 

出版商: Wiley Subscription Services, Inc., A Wiley Company

 

关键词: recurrent noncystic low‐grade astrocytomas;chemotherapy;surgery;radiation therapy

 

数据来源: WILEY

 

摘要:

AbstractSix children with grade II astrocytomas were treated with combination chemotherapy consisting of 1,3 bis(2‐chloroethyl) 1‐nitrosourea (BCNU), Vincristine (VCR), intrathecal Methotrexate (i.t. MTX), and Dexamethasone. Of the children, 3 showed a partial remission, and 1 other showed clinical improvement. Our data suggest that chemotherapy is effective in low‐grade astrocytomas, and there is now a need for larger trials in low‐grade astrocytomas to document the role of chemotherapy accurately in these tumors. It is suggested that trials of chemotherapy as adjuvant to surgery and radiotherapy should be in

 

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