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An analysis of structural aberrations in human sperm chromosomes

 

作者: B.F. Brandriff,   L.A. Gordon,   D. Moore, II,   A.V. Carrano,  

 

期刊: Cytogenetic and Genome Research  (Karger Available online 1988)
卷期: Volume 47, issue 1-2  

页码: 29-36

 

ISSN:1424-8581

 

年代: 1988

 

DOI:10.1159/000132500

 

出版商: S. Karger AG

 

数据来源: Karger

 

摘要:

We have analyzed structural aberrations in 5,000 sperm chromosome complements obtained from 20 men over a 5-yr period by fusion of human sperm with hamster eggs. Detailed data are presented on 366 abnormal cells with 379 analyzable breakpoints. The frequency of cells with structural aberrations ranged from 1.9% to 14.5% among donors; this interindividual variability was statistically significant (p < 0.0001). In contrast, repeat samples from individual men showed no significant variation over time. The number of sperm chromosome sets processed per hamster egg had no effect on the frequency with which structural aberrations occurred, nor were sperm chromosome abnormalities altered by varying capacitation or culture conditions. The spectrum of structural aberrations observed in human sperm chromosomes and a chi-square analysis of breakpoints based on DNA content are presented. Although human sperm chromosome abnormalities were visualized with a cross-species system, we believe that they represent an inherent, biologically significant phenomenon.

 

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