Genetic Association Study between Senile Dementia of Alzheimer’s Type and APOE/C1/C2 Gene Cluster
作者:
Kouzin Kamino,
Aoi Yoshiiwa,
Yumiko Nishiwaki,
Keiko Nagano,
Hideki Yamamoto,
Toshiko Kobayashi,
Yasuhiro Nonomura,
Hiroshi Yoneda,
Toshiaki Sakai,
Masaki Imagawa,
Tetsuro Miki,
Toshio Ogihara,
期刊:
Gerontology
(Karger Available online 1996)
卷期:
Volume 42,
issue 1
页码: 12-19
ISSN:0304-324X
年代: 1996
DOI:10.1159/000213820
出版商: S. Karger AG
关键词: Alzheimer’s disease;Apolipoprotein E;Apolipoprotein C1;Apolipoprotein C2;Genetics
数据来源: Karger
摘要:
Senile dementia of Alzheimer’s type (SDAT) is characterized by progressive deficits of multiple cognitive functions in elderly more than 65 years of age. The APOE-ε4 allele has been shown to be a risk factor for SDAT. To investigate the genetic interactions between SDAT and the APOE/APOC1/APOC2 gene cluster located at 19q13.2, we genotyped these genes in patients with SDAT and nondemented controls. Although allelic associations were found between the APOC1 locus and SDAT (p = 0.0022) as well as between the APOE locus and SDAT (p < 0.0001), no associations were detected between the APOC2 locus and SDAT. And the association between the APOE and APOC1 locus in SDAT was statistically more significant than that in controls (p < 0.001). Estimation of the haplotype frequencies indicated that the association between the APOE/APOC1 haplotype and SDAT was more significant than linkage disequilibrium between the APOE and APOC1 locus (p < 0.01). These results suggest that genetic interaction between the APOE and APOC1 gene could modify a risk factor of APOE-ε4 for SDAT. The APOE/APOC1 locus was estimated to be responsible for 54.8% of SDAT in the Japanese populat
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