Growth Inhibition ofCandidaalbicansand Other Medically Important Yeasts by Vaginal Contraceptive Products
作者:
Mohammad Shubair,
Bryan Larsen,
期刊:
Gynecologic and Obstetric Investigation
(Karger Available online 1990)
卷期:
Volume 29,
issue 1
页码: 67-70
ISSN:0378-7346
年代: 1990
DOI:10.1159/000293303
出版商: S. Karger AG
关键词: Antifungal;Spermicide;Candida albicans;Boric acid
数据来源: Karger
摘要:
The antifungal effects of two commercially available spermicidal gels (Conceptrol, produced by Ortho Pharmaceutical, Raritan, N.J., and Koromex, produced by Schmid Laboratories, Little Falls, N.J.) as well as pure nonoxynol-9 and boric acid (both components of vaginal contraceptive products) were tested against 50 clinical yeast isolates by the agar dilution method. The formulated products exerted comparable dose-dependent inhibitory effects against all yeasts tested. A 3-fold dilution of the formulated spermicidal products inhibited 90% of the yeast strains tested. To determine if the antifungal effect was due to the spermicidal detergent nonoxynol-9, this compound was tested for antifungal activity but was completely ineffective against Candida albicans in concentrations up to 10%. Boric acid, present in at least one of the products (Koromex), inhibited representative yeasts at a concentration of 0.4%. The relationship of pH and oxygen tension to inhibition by the commercial spermicides was also investigated. The pH values tested ranged from 4 to 7 and had little effect on inhibition; anaerobiosis at pH 7 slightly reduced the inhibitory activity of Conceptrol gel.
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