ABSTRACTIn the present experiment the authors investigated whether the previously found influence of exteroceptive stimulation of the extremities on the elicitation of an allergic or secondary reaction of the skin in guinea‐pigs to DNCB is elaborated via the toxic or primary reaction. An influence of the stimulation on the primary reaction was found too.The experiment was conducted in two parts: 1) Two experimental groups were stimulated electrically on different schedules, continuous or repetitive. A 48 hour interval between stimulation and application of DNCB was added. The skin reactions were rated by 4 observers on a 5‐point rating scale. 2) Two experimental groups were stimulated on the same schedules as above. The corticoid levels were measured at different times after stimulation.The experiment showed that the probability of a skin reaction on the allergic (secondary) contact to a threshold dose was greater for the continuously stimulated group than for the control group.Relationships between corticoid levels and skin reactions were discussed. The hypothesis that stimulation has a direct influence on the allergic contact was suppor