Clopenthixol and flupenthixol depot preparations in outpatient schizophrenics: I. A ONE YEAR DOUBLE‐BLIND STUDY OF CLOPENTHIXOL DECANOATE AND FLUPENTHIXOL PALMITATE
作者:
S. J. Dencker,
M. Lepp,
U. Malm,
期刊:
Acta Psychiatrica Scandinavica
(WILEY Available online 1980)
卷期:
Volume 61,
issue S279
页码: 10-28
ISSN:0001-690X
年代: 1980
DOI:10.1111/j.1600-0447.1980.tb07080.x
出版商: Blackwell Publishing Ltd
关键词: Key words:;Clopenthixol decanoate;flupenthixol palmitate;outpatient schizophrenics;double‐blind;one‐year;maintenance treatment
数据来源: WILEY
摘要:
Clopenthixol decanoate and flupenthixol palmitate, both depot neuroleptics belonging to the thioxanthene group, were studied during double‐blind conditions for 12 months using four week intervals between injections. The 60 patients included in the study were chronic schizophrenics and treated as outpatients after earlier admission to hospital and rehabilitation training periods. They had all been treated with depot neuroleptics in the last three years and they had been free from relapse for at least 15 months. The main aim with this trial was to study the two depot drugs during maintenance treatment conditions in an outpatient setting.Ten patients dropped out, 7 because of unsatisfactory effect, mainly because only limited dose levels were accepted according to the design. In spite of the earlier long lasting neuroleptic treatment and the good social adaptation in this schizophrenic subgroup there was observed a symptom decrease in all the rating scales even in these symptom poor patients. This improvement in psychopathology with optimal results after half a year seems to be a combined result of the efficient neuroleptics tested and careful monitoring of the dru
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