Nifedipine – a Calcium Channel Blocker – in Asthmatic Patients Interaction with Terbutaline
作者:
Karin Svedmyr,
Claes‐Goran Lofdahl,
Nils Svedmyr,
期刊:
Allergy
(WILEY Available online 1984)
卷期:
Volume 39,
issue 1
页码: 17-22
ISSN:0105-4538
年代: 1984
DOI:10.1111/j.1398-9995.1984.tb01928.x
出版商: Blackwell Publishing Ltd
关键词: calcium channel blocking agent;terbutaline;dose‐response effect;hemodynamic effects;skeletal muscle tremor;potentiation
数据来源: WILEY
摘要:
Seven asthmatic patients were studied in a single‐blind randomized, crossover study after oral administration of 20 mg nifedipine or placebo Four increasing doses of i.v. terbutaline were then given with 30 min interval. The study was concluded with inhalation of five terbutaline puffs. FFAV1measurements 30 min after intake of nifedipine did not show any difference compared to placebo. During the terbutaline treatment, however, there was a more pronounced bronchodilation after nifedipine than after placebo (P<0.051. Terbualine‐induced skeletal muscle tremor was similar after nifedipine and placebo pretreatments. After nifedipine intake there was a decrease of diastolic blood pressure and a reflexogenic tachycardia. Thus, this study showed a small potentiation of the beta2‐adrenoceptor mediated bronchodilation. which is of importance when treating patients with simultaneous asthma and hypertension or angina pec
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