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Nifedipine – a Calcium Channel Blocker – in Asthmatic Patients Interaction with Terbutaline

 

作者: Karin Svedmyr,   Claes‐Goran Lofdahl,   Nils Svedmyr,  

 

期刊: Allergy  (WILEY Available online 1984)
卷期: Volume 39, issue 1  

页码: 17-22

 

ISSN:0105-4538

 

年代: 1984

 

DOI:10.1111/j.1398-9995.1984.tb01928.x

 

出版商: Blackwell Publishing Ltd

 

关键词: calcium channel blocking agent;terbutaline;dose‐response effect;hemodynamic effects;skeletal muscle tremor;potentiation

 

数据来源: WILEY

 

摘要:

Seven asthmatic patients were studied in a single‐blind randomized, crossover study after oral administration of 20 mg nifedipine or placebo Four increasing doses of i.v. terbutaline were then given with 30 min interval. The study was concluded with inhalation of five terbutaline puffs. FFAV1measurements 30 min after intake of nifedipine did not show any difference compared to placebo. During the terbutaline treatment, however, there was a more pronounced bronchodilation after nifedipine than after placebo (P<0.051. Terbualine‐induced skeletal muscle tremor was similar after nifedipine and placebo pretreatments. After nifedipine intake there was a decrease of diastolic blood pressure and a reflexogenic tachycardia. Thus, this study showed a small potentiation of the beta2‐adrenoceptor mediated bronchodilation. which is of importance when treating patients with simultaneous asthma and hypertension or angina pec

 

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