Relative Value of Oestrogen Receptor Assay, Lactoferrin Content, and Glucose-6-Phosphate Dehydrogenase Activity as Prognostic Indicators in Primary Breast Cancer
作者:
W.R. Bezwoda,
D.P. Derman,
Norah See,
Nazima Mansoor,
期刊:
Oncology
(Karger Available online 1985)
卷期:
Volume 42,
issue 1
页码: 7-12
ISSN:0030-2414
年代: 1985
DOI:10.1159/000225992
出版商: S. Karger AG
关键词: Breast cancer;Oestrogen receptor;Lactoferrin glycolytic enzymes
数据来源: Karger
摘要:
Oestrogen receptor content, lactoferrin, hexokinase, and glucose-6-phosphate dehydrogenase levels were measured in cytosol from 25 primary breast cancers and 3 fibroadenomas. Both hexokinase and glucose-6-phosphate dehydrogenase activity were higher in malignant tissue as compared to benign breast lesions. Oestrogen receptor concentration and lactoferrin content failed to predict the development of metastatic disease, while glucose-6-phosphate dehydrogenase activity was significantly higher in cytosol from those tumours which subsequently metastasized compared to those which remained localized.
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