Circulating Clq Binding Complexes in Inflammatory Bowel Diseases
作者:
E. Einstein,
C. Charland,
W.R. Thayer, jr.,
期刊:
Digestion
(Karger Available online 1979)
卷期:
Volume 19,
issue 1
页码: 65-69
ISSN:0012-2823
年代: 1979
DOI:10.1159/000198324
出版商: S. Karger AG
关键词: Antigen antibody complex;Colectomy;Complement;Ileostomy;Inflammatory bowel disease;Regional enteritis;Ulcerative colitis
数据来源: Karger
摘要:
To determine whether circulating immune complexes are present in the sera of patients with inflammatory bowel disease (IBD), a 125I-Clq binding assay was performed. Of the 55 IBD serum samples tested, the 24 ulcerative colitis samples demonstrated significant binding (33.1 ± 8.3%, p = 0.02), whereas the 31 Crohn’s samples bound essentially normal amounts (29.2 ± 7.4%). A positive control group consisting of 27 patients with rheumatoid arthritis was also studied. Sera from 4 patients with IBD and colonic cancer when tested, bound 40.2 ± 8.0% of the available 125I-Clq, while 10 patients with previous colectomies and ileostomies gave results similar to those of 15 healthy controls and 11 patients with irritable c
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