Flavonoids protect LDL from oxidation and attenuate atherosclerosis
作者:
Bianca Fuhrman,
Michael Aviram,
期刊:
Current Opinion in Lipidology
(OVID Available online 2001)
卷期:
Volume 12,
issue 1
页码: 41-48
ISSN:0957-9672
年代: 2001
出版商: OVID
数据来源: OVID
摘要:
Consumption of some plant-derived flavonoids results in their absorption and appearance in plasma and tissues. The inverse relationship between dietary flavonoids consumption and cardiovascular diseases may be associated with the ability of flavonoids to attenuate LDL oxidation, macrophage foam cell formation and atherosclerosis. The effect of flavonoids on arterial cell-mediated oxidation of LDL is determined by their accumulation in the lipoprotein and in arterial cells, such as macrophages. Flavonoids can reduce LDL lipid peroxidation by scavenging reactive oxygen/nitrogen species, chelation of transition metal ions and sparing of LDL-associated antioxidants. They can also reduce macrophage oxidative stress by inhibition of cellular oxygenases [such as nicotinamide adenine dinucleotide phosphate, reduced form (NADPH) oxidase] or by activating cellular antioxidants (such as the glutathione system). Thus, plant flavonoids, as potent natural antioxidants that protect against lipid peroxidation in arterial cells and lipoproteins, significantly attenuate the development of atherosclerosis.
点击下载:
PDF
(113KB)
返 回