Oxidants and antioxidants in atherosclerosis
作者:
Ryuichi Mashima,
Paul Witting,
Roland Stocker,
期刊:
Current Opinion in Lipidology
(OVID Available online 2001)
卷期:
Volume 12,
issue 4
页码: 411-418
ISSN:0957-9672
年代: 2001
出版商: OVID
数据来源: OVID
摘要:
The oxidative theory suggests that LDL oxidation contributes to atherogenesis, implying that attenuation of this process by antioxidants should decrease atherosclerosis. However, a causative link between LDL oxidation and atherogenesis is not firmly established. It requires the identification of the oxidants that are responsible for the initiation of LDL oxidation, and an understanding of the modified moieties that are responsible for the proatherogenic activities of oxidized LDL. The present review summarizes recent data on potential biological oxidants for LDL in the vessel wall, and discusses the antiatherogenic role(s) of selected antioxidants.
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