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Comparison of Current Alkylating Agents with a Homo-aza-Steroidal Ester for Antineoplastic Activity

 

作者: Panayotis Catsoulacos,   Athanasios Papageorgiou,   Elizabeth Margarity,   Dionysis Mourelatos,   Eleftheria Mioglou,  

 

期刊: Oncology  （Karger Available online 1994）
卷期: Volume 51, issue 1  

页码: 74-78

 

ISSN:0030-2414

 

年代: 1994

 

DOI:10.1159/000227314

 

出版商: S. Karger AG

 

关键词: Alkylating agents;Antitumor activity

 

数据来源: Karger

 

摘要:

The modified steroidal alkylating agent, 17β-hydroxy-3-aza-A-homo-4α-androsten-4-one-p-bis(2-chloroethyl)aminophenoxyacetate has been tested against L1210 and P388 leukemias, and Lewis lung cancer, on DNA synthesis of EAT, L1210, P388, and BHK cell cultures, and on the induction of sister chromatid exchange. Comparable studies in vivo and in vitro were also done with p-bis(2-chloroethyl)aminophenoxyacetic acid, cyclophosphamide, melphalan, and chlorambuci

 

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