Enchancement of Deficient Pituitary Response to Luteinizing Hormone Releasing Hormone in Patients With Primary Amenorrhea
作者:
G. SERRA,
P. MUSCATELLO,
E. MENINI,
G. LAFUENTI,
R. CANIGLIA,
期刊:
Obstetrics & Gynecology
(OVID Available online 1975)
卷期:
Volume 45,
issue 5
页码: 523-526
ISSN:0029-7844
年代: 1975
出版商: OVID
数据来源: OVID
摘要:
Although the absence of pituitary response to the luteinizing hormone releasing hormone (LHRH) test has been considered proof of a lesion primarily localized at the pituitary level, the possibility exists that an absent pituitary response may represent only the effect of a chronic deficiency of hypothalamic secretion. To verify this hypothesis, 4 patients with primary amenorrhea, hypogonadotropic hypogonadism, and deficient or absent response to a 25 μg LHRH rapid IV test were treated with 400 μg LHRH infused in 7 hours during each of 3 successive days. The finding that patients with deficient LH responses to a rapid LHRH test became normally responsive to a second equivalent test after a slow and prolonged treatment with the decapeptide suggests that, in these patients, besides a lesion at the pituitary level, a primary defect at the hypothalamic or higher centers may also be suspected.
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