Sensitizing capacity of 2‐methylol phenol, 4‐methylol phenol and 2, 4, 6‐trimethylol phenol in the guinea pig
作者:
Magnus Bruze,
期刊:
Contact Dermatitis
(WILEY Available online 1986)
卷期:
Volume 14,
issue 1
页码: 32-38
ISSN:0105-1873
年代: 1986
DOI:10.1111/j.1600-0536.1986.tb01149.x
出版商: Blackwell Publishing Ltd
关键词: Delayed hypersensitivity;high pressure liquid chromatography;methylol phenols;phenol‐formaldehyde resins
数据来源: WILEY
摘要:
The sensitizing capacities of 2‐methylol phenol (2‐MP), 4‐methylol phenol (4‐MP) and 2,4,6‐inmethylol phenol (2,4,6‐MP) were investigated with the guinea pig maximization test. These compounds are known sensitizers in phenol‐formaldehyde resins. The study was performed in order to assess and compare the degree of the sensitizing capacities of these chemically related substances. The animals were also rechallenged with the sensitizer and 5 chemically related compounds in order to study the cross‐reaction patterns.2‐MP Was demonstrated to be a strong sensitizer, 4‐MP a moderate sensitizer and 2,4,6‐MP a weak sensitizer. With 2‐MP as the sensitizer, o‐cresol and 2,4‐dimethyl phenol were possible cross‐reacting substances, p‐cresol and 2.4‐dimethylol phenol were possible cross‐reacting compounds for 4‐MP.The chemical investigation by high pressure liquid chromatography indicated that the com
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