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Comparison of the Role of Testosterone and Methyltestosterone in Developing Chloroform-Induced Renal Tubular Necrosis in Mice

 

作者: S. Kruś,   A. Naciążek-Wieniawska,   Z. Zaleska-Rutczyńska,  

 

期刊: Nephron  （Karger Available online 1975）
卷期: Volume 15, issue 1  

页码: 69-73

 

ISSN:1660-8151

 

年代: 1975

 

DOI:10.1159/000180494

 

出版商: S. Karger AG

 

关键词: Testosterone;Methyltestosterone;Renal tubular necrosis;Chloroform intoxication

 

数据来源: Karger

 

摘要:

The presence of testosterone is a prerequisite for the development of chloroform-induced renal tubular necrosis in mice. The purpose of this study was to check whether methyltestosterone exerts the same influence. Castrated males and females were treated with one of these compounds: those treated with testosterone developed renal tubular necrosis after chloroform injection, those which received methyltestosterone were free of this lesion.

 

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