Concentration of cefaclor in human prostatic tissue
作者:
RAYMOND SMITH,
GEORGE SCHMID,
ALDONA BALTCH,
NANCY SUTPHEN,
MARK HAMMER,
期刊:
The American Journal of the Medical Sciences
(OVID Available online 1981)
卷期:
Volume 281,
issue 1
页码: 19-24
ISSN:0002-9629
年代: 1981
出版商: OVID
关键词: Cefaclor;Prostatic Tissue;Prostatitis
数据来源: OVID
摘要:
Concentration of cefaclor, a new oral cephalosporin, was measured in prostatic tissue of ten patients undergoing suprapubic prostatectomy. The average prostatic tissue concentrations were 0.51 — 0.22 microgram and 0.74 — 0.67 microgram per gram of tissue following the oral administration of 250-milligram and 500-milligram doses, respectively. The prostate/plasma ratios of cefaclor were approximately 0.7 indicating no evidence of accumulation of the drug in prostatic tissue. Levels of cefaclor achieved in human prostatic disease are equal to or less than the minimum inhibitory concentration of most strains of known facultative bacterial pathogens associated with prostatitis.
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