Influence of Biosynthetic Human Growth Hormone on the Biomechanical Strength Development in Skin Incisional Wounds of Diabetic Rats
作者:
M. Seyer-Hansen,
T.T. Andreassen,
P.H. Jørgensen,
H. Oxlund,
期刊:
European Surgical Research
(Karger Available online 1993)
卷期:
Volume 25,
issue 3
页码: 162-168
ISSN:0014-312X
年代: 1993
DOI:10.1159/000129273
出版商: S. Karger AG
关键词: Diabetes mellitus;Wound healing;Growth hormone;Somatotropin;Mechanical strength;Rat
数据来源: Karger
摘要:
The influence of biosynthetic human growth hormone (b-hGH) on the mechanical strength development of skin incisional wounds in diabetic rats has been investigated after 4, 7 and 21 days of healing. Diabetes caused decreased mechanical strength of the wounds. After 21 days of healing, the diabetic animals treated with b-hGH from 7 days before wound infliction had an increased maximum load (14%) compared with the untreated diabetic animals. After 4 and 7 days of healing, no differences in the bîomechanical strength of diabetic wounds with and without b-hGH treatment were found. The diabetic animals receiving b-hGH showed a significant increase in body weight compared with the untreated diabetic animals. In the diabetic animals, the blood glucose concentration was increased by treatment with b-hGH. In conclusion, treatment with b-hGH from 7 days before operation can counteract the reduced mechanical strength of skin wounds in diabetic rats on day 21
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