Examination of Newly Synthesized 2-Chloroethyl-nitrosoureas on Rat Leukemia L 5222
作者:
W.J. Zeller,
G. Eisenbrand,
期刊:
Oncology
(Karger Available online 1981)
卷期:
Volume 38,
issue 1
页码: 39-42
ISSN:0030-2414
年代: 1981
DOI:10.1159/000225519
出版商: S. Karger AG
关键词: 2-Chloroethylnitrosoureas;Rat leukemia L 5222
数据来源: Karger
摘要:
The preterminal intraperitoneal implanted rat leukemia L 5222 was used to test the chemotherapeutic activity of 10 newly synthesized nitrosoureas: ethylmethanesulfonato-CNU, acetamido-CNU, dihydroxy-propyl-CNU, carboxyethyl-CNU, cyanoethyl-CNU, morpholino-CNU, piperidino-CNU, methylene-dioxybenzyl-CNU, methylene-3-pyridyl-CNU and methylene-4-pyridyl-CNU; their activity was compared against BCNU, CCNU, MeCCNU and hydroxyethyl-CNU. All compounds tested showed a more or less pronounced chemo-therapeutic activity. MeCCNU was superior to all other compounds investigated. The predictive value for human tumors of results obtained from a model which is highly sensitive to nitrosoureas is discussed.
点击下载:
PDF
(1560KB)
返 回