A Technique to Obtain and Process Surgical Specimens of the Human Vestibular Aqueduct for Histopathological Studies of the Endolymphatic Duct and Sac
作者:
Niklas Danckwardt-Lillieström,
Helge Rask-Andersen,
Fred H. Linthicum,
William F. House,
期刊:
ORL
(Karger Available online 1992)
卷期:
Volume 54,
issue 4
页码: 215-219
ISSN:0301-1569
年代: 1992
DOI:10.1159/000276301
出版商: S. Karger AG
关键词: Endolymphatic sac;human;Surgery;Transmission electron microscopy;Ménière’s disease
数据来源: Karger
摘要:
The endolymphatic sac (ES) may play a crucial role in the pathophysiology of Ménière’s disease. This paper presents a technique to obtain and process fresh human specimens of the endolymphatic duct (ED) and the presumably more active intraosseous portion of the ES obtained at surgery. The specimens are preserved with an intact bony shell around the ED and the intraosseous ES. This allows ultrastructural histopathological evaluation of the intraluminal contents, the epithelium and the subepithelial tissue as well as the mutual relationships of these structures. Various factors influencing ES ultrastructure are discussed. The results obtained from this method may increase our understanding of the possible role of the ES in the etiology of different inner ear disord
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