Effects of Aminergic Drugs and Glutamic Acid on Audiogenic Seizures Induced by Early Exposure to Ethanol
作者:
Joseph Yanai,
Paul Y. Sze,
Benson E. Ginsburg,
期刊:
Epilepsia
(WILEY Available online 1975)
卷期:
Volume 16,
issue 1
页码: 67-71
ISSN:0013-9580
年代: 1975
DOI:10.1111/j.1528-1157.1975.tb04722.x
出版商: Blackwell Publishing Ltd
关键词: Alcohol;Seizures;Amines;Glutamate
数据来源: WILEY
摘要:
SUMMARYAdult C57BL/lOBg mice, normally resistant to audiogenic seizures, became susceptible when the mothers drank 10%ethanol in water during pregnancy and for 14 days postpartem. Reserpine enhanced the incidence of seiqres, and the effect was reversed by 5‐hydrOxYtryp tophan but not by dihydroxyphenylalanine p‐Chlorophenylalanine also enhanced the inci dence of seizures, whereas a‐methyl‐p‐tyrosine did not effect. Monosodium glutamate almost completely prevented seizures. These results are consistent with the interpretation that the serotonergic systems may be among those involved in the seizure mechanism induced by fetal and early exposure t
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