Intrathecal Cytostatic Chemotherapy of Meningitis carcinomatosa
作者:
D. Dommasch,
H. Przuntek,
W. Grüninger,
H.G. Mertens,
期刊:
European Neurology
(Karger Available online 1976)
卷期:
Volume 14,
issue 3
页码: 178-191
ISSN:0014-3022
年代: 1976
DOI:10.1159/000114739
出版商: S. Karger AG
关键词: Meningitis carcinomatosa;CSF cytology;Intrathecal chemotherapy;Metastatic carcinoma of the breast
数据来源: Karger
摘要:
Effects of intrathecal cytostatic chemotherapy on the clinical symptoms and cerebrospinal fluid (CSF) findings are being demonstrated in a case of metastatic carcinoma of the breast with signs of meningeal irritation and cranial nerve involvement. Clinical symptoms disappeared after repeated intrathecal applications of methotrexate. CSF cell counts were reverted to normal but tumor cells were found to be persistant in CSF over a period of 19 months. Risks of combined intrathecal and systemic cytostatic therapy and possible effects of parenteral citrovorum factor applications are being discussed. The importance of continued intrathecal chemotherapy and of regular and thorough examination of CSF cells in meningitis carcinomatosa is emphasized. Cytological methods included investigations on viable CSF cells.
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