Pathologic Sideroblasts and Siderocytes Associated with Chloramphenicol Therapy in a Dog
作者:
John W. Harvey,
Karen J. Wolfsheimer,
Charles F. Simpson,
Tracy W. French,
期刊:
Veterinary Clinical Pathology
(WILEY Available online 1985)
卷期:
Volume 14,
issue 1
页码: 36-42
ISSN:0275-6382
年代: 1985
DOI:10.1111/j.1939-165X.1985.tb00844.x
出版商: Blackwell Publishing Ltd
关键词: sideroblasts;siderocytes;chloramphenicol;canine erythrocytes;canine bone marrow
数据来源: WILEY
摘要:
SummarySiderotic granules were recognized in blood erythrocytes from a male Boxer dog with suppurative prostatitis, cystitis and pyelonephritis that was being given high dosage chloramphenicol therapy. Siderotic inclusions were recognized in the cytoplasm of 96% of the rubricytes and metarubricytes in a bone marrow aspirate. Siderotic inclusions were numerous and in some cases formed a ring around the nucleus. This peri‐nuclear location suggested that pathologic mitochondrial iron accumulation had occurred, resulting in the formation of “ringed” sideroblasts. The occurrence of pathologic sideroblasts was confirmed by electron microscopy. Blood siderocytes and bone marrow sideroblasts disappeared after cessation of chloramphenicol th
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