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A Study of the Conditions and Accuracy of the Thrombin Time Assay of Plasma Fibrinogen

 

作者: Jørgen Jespersen,   Johannes Sidelmann,  

 

期刊: Acta Haematologica  (Karger Available online 1982)
卷期: Volume 67, issue 1  

页码: 2-7

 

ISSN:0001-5792

 

年代: 1982

 

DOI:10.1159/000207017

 

出版商: S. Karger AG

 

关键词: Acute phase protein;Plasma fibrinogen

 

数据来源: Karger

 

摘要:

The conditions, accuracy, precision and possible errors of the thrombin time assay of plasma fibrinogen are determined. Comparison with an estimation of clottable protein by absorbance at 280 nm gave a correlation coefficient of 0.96 and the regression line y = 1.00 × + 0.56 (n = 34). Comparison with a radial immunodiffusion method yielded the correlation coefficient 0.97 and the regression line y = 1.18 × = 2.47 (n = 26). The presence of heparin in clinically applied concentrations produced a slight shortening of the clotting times. The resulting error in the estimated concentrations of fibrinogen was too small to affect the clinical usefulness of the determinations. The influence of fibrin(ogen) degradation products was significant only in excessive amounts in samples containing low levels of fibrinoge

 

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