The Efficacy and Safety of Tianeptine in the Treatment of Depressive Disorder: Results of a Controlled Double-Blind Multicentre Study vs. Amitriptyline
作者:
G. Invernizzi,
E. Aguglia,
A. Bertolino,
M. Casacchia,
N. Ciani,
G.F. Marchesi,
M. Nardini,
V. Rapisarda,
期刊:
Neuropsychobiology
(Karger Available online 1994)
卷期:
Volume 30,
issue 2-3
页码: 85-93
ISSN:0302-282X
年代: 1994
DOI:10.1159/000119142
出版商: S. Karger AG
关键词: Antidepressants;Tianeptine;Amitriptyline;Depression;Anxiety;Somatic complaints;Efficacy;Acceptability
数据来源: Karger
摘要:
Three hundred in- and outpatients suffering from depressive disorder, as diagnosed using DSM-III criteria were treated for 6 weeks under double-blind conditions in a multicenter controlled study of tianeptine vs. amitriptyline. Both groups presented steady improvement of depressive syndrome from day 7 up to the end of the treatment, as shown by all evaluation scales: HDRS, SAD, CGI. Furthermore, anxiety linked to the depressive syndrome decreased equally in both groups, as shown by the HARS measurements. In addition to the improvement of mood, the tianeptine-treated patients presented less somatic complaints and side effects when compared to the reference antidepressant. These results confirm previous findings that tianeptine is an effective antidepressant with a lower side effect profile than amitriptyline.
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