Antisperm antibodies and lymphocyte subsets in semen—not a simple relationship
作者:
C. L. R. BARRATT,
P. E. HARRISON,
A. ROBINSON,
I. D. COOKE,
期刊:
International Journal of Andrology
(WILEY Available online 1990)
卷期:
Volume 13,
issue 1
页码: 50-58
ISSN:0105-6263
年代: 1990
DOI:10.1111/j.1365-2605.1990.tb00959.x
出版商: Blackwell Publishing Ltd
关键词: white blood cells;antisperm antibodies;T lymphocytes
数据来源: WILEY
摘要:
SummaryThe significance of white blood cells in the ejaculate remains a matter of controversy. Several authors have suggested that such cells are important in the modulation of an antisperm antibody response, i.e. a predominance of suppressor/cytotoxic to helper/inducer T cells may prevent the development of antisperm antibodies. In order to examine this relationship further we have documented the white blood cell types, with emphasis on the T‐lymphocyte populations, in the ejaculates of men from infertile couples with and without antisperm antibodies; the latter group was divided further into two groups—vasovasostomized men and idiopathic men. All seven of the men without antisperm antibodies had a predominance of suppressor/cytotoxic T cells to helper/inducer T cells in the ejaculate. However, only in some of the men with antibodies was there a predominance of T‐helper/inducer cells. It is clear that the relationship between antisperm antibodies and seminal leucocytes is therefore not as straightforward as has been pro
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