Procedures for indwelling central venous catheter care (ICVC) vary from utilization of strict, lengthy procedures to more lenient ones. Nurses on a hematology/oncology unit wanted to change the current ICVC care procedure to one that required fewer supplies and less time, yet was effective in minimizing catheter related infections. This prospective, quasi-experimental study of adult hospitalized hematology/oncology patients compared the rate of ICVC-related infections in an established catheter care procedure group (n - 21) and a treatment group (n = 36) using two different procedures for catheter care. Additional data examined were factors likely to increase infection risk, inflammation at catheter entrance and exit sites, and catheter complications. Broviac, Cook, and Hickman catheters were inserted. Descriptive statistics and the chi-square test, p > 0.05, were used for data analysis. The findings indicated no significant difference in the incidence of catheter-related infections in the treatment and control groups. A neutrophil count of under 22% was the only common factor likely to increase the risk for infections. The most common catheter complications, excluding infection, were dysfunction and displacement. Exit site erythema of 1.1–3.0 cm was correlated with local catheter infections. A shorter catheter care procedure may be as effective as longer procedures in minimizing catheter related infections.