Adherent Spleen Cell Production of E Series Prostaglandins in Rats Bearing Variants of the R3327 Dunning Prostatic Adenocarcinoma: Effect of Cyclophosphamide
作者:
RubensteinM.,
ShawM. W.,
DubinA.,
GuinanP. D.,
期刊:
Immunopharmacology and Immunotoxicology
(Taylor Available online 1986)
卷期:
Volume 8,
issue 2
页码: 145-163
ISSN:0892-3973
年代: 1986
DOI:10.3109/08923978609028613
出版商: Taylor&Francis
数据来源: Taylor
摘要:
AbstractProstaglandins of the E series (PGE) have been implicated in many facets of immunoregulation, as well as having a possible role in metastatic dissemination. Variant sublines of the Dunning R3327 rat prostatic adenocarcinoma, differing in growth rate, hormonal responsiveness and in propensity for metastasis, were carried in Fisher×Copenhagen F1 animals. Adherent spleen cells were assayed in vitro for their ability to convert arachidonic acid to prostaglandins of the E series. These glass adherent cells presumably include the monocytic and T cell populations which have been implicated as being immunoregulatory. The results indicated that those spleen cells obtained from animals carrying the metastatic R3327-MAT-LyLu subline tumor converted more arachidonic acid to PGE's than cells derived from animals bearing non-metastatic sublines. Cyclophosphamide therapy did not alter such conversion. Multiple regulatory mechanisms for prostaglandin metabolism are suggested.
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