The polyprotein nature of substance P precursors
作者:
James E. Krause,
Margaret R. Macdonald,
Yasuo Takeda,
期刊:
BioEssays
(WILEY Available online 1989)
卷期:
Volume 10,
issue 2‐3
页码: 62-69
ISSN:0265-9247
年代: 1989
DOI:10.1002/bies.950100207
出版商: Wiley Subscription Services, Inc., A Wiley Company
数据来源: WILEY
摘要:
AbstractSubstance P and related tachykinin peptides probably act as neurotransmitters or modulators of neurotransmission, and regulate biological processes as diverse as salivary secretion and transmission of pain signals. Substance P peptide sequences are expressed in three distinct mRNAs that are generated from one gene by differential RNA splicing. In addition to substance P, as many as three other tachykinin peptides can be generated from the polyprotein precursors by differential posttranslational processing. Three tachykinin receptor subtypes have been extensively characterized which differentially interact with the naturally occurring tachykinin peptides. Therefore, the generation of diversity of tachykinin peptides results from differential precursor RNA splicing and differential posttranslational processing. The specificity of peptide responses is the result of selective receptor subtype expression.
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