首页   按字顺浏览 期刊浏览 卷期浏览 Low Molecular Weight Immunosuppressive Factors Found in Elevated Amounts in Cancer Asci...
Low Molecular Weight Immunosuppressive Factors Found in Elevated Amounts in Cancer Ascitic Fluids of Mice 1. Isolation, Identification and Immunosuppressive Effects of Uric Acid and Uracil

 

作者: SaimShunsuke,   TakanoShoichi,   MajimaToshiro,   AsoHisashi,   NakamuraTakehiko,   IshidaNakao,  

 

期刊: Immunopharmacology and Immunotoxicology  (Taylor Available online 1986)
卷期: Volume 8, issue 1  

页码: 39-58

 

ISSN:0892-3973

 

年代: 1986

 

DOI:10.3109/08923978609031084

 

出版商: Taylor&Francis

 

数据来源: Taylor

 

摘要:

AbstractA definite increase in two low molecular weight factors, G10-2 and G10-3 was found in Ehrlich ascitic fluids, parallel to tumor growth. The isolation and identification of the two factors were attempted through gel filtration and reversed phase column chromatography, using ascitic fluids obtained 13 days after intraperitoneal implantation of Ehrlich tumor cells. As a result, two highly purified factors were observed upon examination by high performance liquid chromatography. Additional analytical data, collected by UV spectrum, NMR spectrum and mass analysis. allowed us to identify G10-2 as uric acid and G10-3 as uracil.Detailed immunological analysis of uric acid and uracil revealed that the augmenting activities of mouse and human NK cells by mouse IFNδ/βor human rIFNδA/D were impaired in the presence of either compound at concentrations of 0.07 mM, the concentration detectable in theascitic fluidof tumor bearing mice.

 

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