Analysis of genetic variation in the Belgian Blue Cattle breed using DNA sequence polymorphism at the growth hormone, low density lipoprotein receptor, α‐subunit of glycoprotein hormones and thyroglobulin loci
作者:
P. HILBERT,
A. MARCOTTE,
A. SCHWERS,
R. HANSET,
G. VASSART,
M. GEORGES,
期刊:
Animal Genetics
(WILEY Available online 1989)
卷期:
Volume 20,
issue 1
页码: 383-394
ISSN:0268-9146
年代: 1989
DOI:10.1111/j.1365-2052.1989.tb00894.x
出版商: Blackwell Publishing Ltd
关键词: cattle;RFLP;nucleotide diversity;mutation rate
数据来源: WILEY
摘要:
Summary.New DNA sequence polymorphisms were identified at four bovine autosomal loci: growth hormone, low density lipoprotein receptor, α‐subunit of glycoprotein hormones and thyroglobulin. Assuming independent assortment between these polymorphisms, the probabilities to be heterozygous at these four loci are 0.48, 0.36, 0.10 and 0.77 respectively, within the Belgian Blue Cattle breed (BBCB). Nucleotide diversity was estimated, showing that animals from the BBCB are heterozygous for 1/1450 nucleotides, a value significantly lower than the 1/500 value found in man. Moreover, we have estimated that the mutation rate at the cytosines of CG dinucleotides is about 10 times higher than that for other nucleotid
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