Prophylactic External Irradiation in Differentiated Thyroid Cancer: A Retrospective Study over a 30-Year Observation Period
作者:
Olga Ésik,
György Németh,
József Eller,
期刊:
Oncology
(Karger Available online 1994)
卷期:
Volume 51,
issue 4
页码: 372-379
ISSN:0030-2414
年代: 1994
DOI:10.1159/000227368
出版商: S. Karger AG
关键词: Papillary;Follicular;Thyroid;Carcinoma;External irradiation;Survival;Local/regional relapse
数据来源: Karger
摘要:
Following surgery which left no macroscopic residue, 114 patients with differentiated thyroid cancer (58 papillary, 56 follicular) were subgrouped on the basis of the dose of externally applied prophylactic postoperative radiation: group 1 received an adequate dose of radiation (≥4,500 cGy of telecobalt, ≥4,000 R of orthovoltage therapy), while group 2 received an inadequate dose of radiation (this group included non-irradiated patients). Local/regional-relapse-free survival (LRRFS), distant-metastatic-relapse-free survival (DMRFS) and total-cause-specific survival (TCSS) were calculated by means of life-table analysis for each histologic type. TCSS and LRRFS were significantly (p < 0.001) better for group 1 in papillary cancer. No difference was found in DMRFS. LRRFS was significantly (p < 0.001) better for group 1 in follicular cancer. No differences were found in TCSS and DMRFS. We conclude that (1) prophylactic postoperative external irradiation is an effective method for survival prolongation in papillary cancer, reducing local/regional recurrences, and (2) external irradiation should be considered in the postoperative management of follicular cancer, to diminish local/regional rela
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