The prognostic significance of bridging hepatic necrosis in chronic type B hepatitis: a histopathologic study
作者:
Tong‐Jong Chen,
Yun‐Fan Liaw,
期刊:
Liver
(WILEY Available online 1988)
卷期:
Volume 8,
issue 1
页码: 10-16
ISSN:0106-9543
年代: 1988
DOI:10.1111/j.1600-0676.1988.tb00960.x
出版商: Blackwell Publishing Ltd
关键词: bridging hepatic necrosis;cirrhosis;chronic type B hepatitis;spotty necrosis
数据来源: WILEY
摘要:
ABSTRACT—A histopathologic follow‐up study was conducted in 207 consecutive patients to examine the prognostic significance of bridging hepatic necrosis (BHN) in chronic type B hepatitis. One hundred and eight patients showed BHN and the other 99 intralobular spotty necrosis (SN) on initial biopsy. A higher proportion of patients with BHN healed (45.4% vs 26.4%) or developed cirrhosis (18.3% vs 3%) than the patients with SN. In contrast, intralobular inflammation persisted or recurred more frequently in the SN than in the BHN group (40.4% vs 5.6%). These figures were statistically significant (P<0.001). Alternatively, 87% of the patients who developed cirrhosis had had BHN as their initial histologic presentations. The estimated relative risk of cirrhotic progression for the BHN group compared to the SN group was 4:1. We conclude that BHN is a paradoxical prognostic factor, either for healing, or cirrhotic progress
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