IgG subclass distribution and relative functional affinity of thyroid microsomal antibodies in postpartum thyroiditis
作者:
A. P. WEETMAN,
H. Y. M. FUNG,
C. J. RICHARDS,
A. M. McGREGOR,
期刊:
European Journal of Clinical Investigation
(WILEY Available online 1990)
卷期:
Volume 20,
issue 2Part1
页码: 133-136
ISSN:0014-2972
年代: 1990
DOI:10.1111/j.1365-2362.1990.tb02259.x
出版商: Blackwell Publishing Ltd
关键词: IgG subclasses;postpartum thyroiditis;thyroid microsomal/peroxidase antibodies
数据来源: WILEY
摘要:
AbstractAn association between the development of postpartum hypothyroidism and high levels of IgG1subclass microsomal (M) antibodies has been reported. Using an assay designed to detect reasonable levels of all the four IgG subclasses, we found no differences in the proportion of each IgG subclass in M antibodies of patients with postpartum hyperthyroidism or hypothyroidism compared with control postpartum patients with M antibodies but no thyroid dysfunction. However the total amount of M antibody of each IgG subclass was elevated above the controls in the patients with thyroid dysfunction. The relative functional affinity of M antibodies did not differ between controls and patients with hypothyroidism but declined 5 and 10–12 months after delivery compared to values at 2 months. These results do not support the suggestion that the amount of IgG1subclass M antibodies particularly determines the course of postpartum thyroiditis. Rather, the total M antibody level, in all four subclasses, is associated with clinical outcome. Resolution of the disease, despite persisting M antibodies, may occur in part because the relative functional affinity of these antibodies declines after deliver
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